3260人のアンギナ不安定患者のプラバスタチンの効果:LIPID研究の結果
A M Tonkin1, D Colquhoun, J Emberson
1National Heart Foundation of Australia, Melbourne, Victoria. Andrew.Tonkin@heartfoundation.com.au
Lancet (London, England)
|December 29, 2000
まとめ
不安定なアンギナや心筋梗塞の患者は,同様の長期的な予後をしており,プラバスタチン療法から利益を得ています. プラバスタチンは,両方のグループで心血管疾患を減少させ,冠動脈疾患の二次予防のための結果を改善します.
科学分野:
- 心臓病学 心臓病学
- クリニック・トライアル 臨床試験
- 薬理学 薬理学とは
背景:
- 低血圧性疾患におけるプラバスタチンによる長期介入 (LIPID) 研究は,冠動脈疾患の二次予防を調査した.
- このサブスタディは,以前不安定なアンギナや心筋梗塞を患った患者に焦点を当てました.
研究 の 目的:
- 前回の不安定なアンギナと心筋梗塞の患者の心血管リスクを比較する.
- これらの患者グループにおける二次予防におけるプラバスタチンの有効性を評価する.
主な方法:
- 3260人の不安定なアンギナと5754人の心筋梗塞患者は,プラバスタチンまたはプラセボにランダムに割り当てられました.
- 治療期間は平均6.0年であり,心血管疾患はコックスの比例リスクモデルを用いて分析された.
主要な成果:
- プラバスタチンは,同様の相対的な死亡リスク低下 (20.6%MI, 26.3%UA) を示した.
- プラバスタチンは,心筋梗塞のグループにおける冠動脈エンドポイントを有意に低下させた.
- 不安定性 angina の患者では,プラバスタチンは,CHD 死亡率,全死亡率,MI,再血管化の必要性,入院率を低下させました.
結論:
- 心筋梗塞や不安定なアンギナを生き延びた患者は,同様の長期的な予後を示しています.
- 両グループとも,その後の不安定な胸痛の発生率が高い.
- プラバスタチン治療は,両方の患者集団における二次予防に類似した利点を提供します.
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