病原体負荷と心筋梗塞または死亡のリスクに関する将来的な研究
1Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA.
Circulation
|January 4, 2001
まとめ
感染症は,冠動脈疾患 (CAD) の患者の心筋梗塞 (MI) と死亡のリスクを高めます. CMVやHAVなどの感染症によるより高い病原体負荷は,リスクの増加と相関しています.
科学分野:
- 感染症 感染症は感染症です.
- 心血管医学 心血管医学
- 免疫学 免疫学とは
背景:
- 以前の横断的な研究では,病原体負荷と冠動脈疾患 (CAD) のリスクが関連していました.
- この前向きな研究では,CAD患者の心筋梗塞 (MI) または死亡に対する病原体負荷の影響を調査しています.
研究 の 目的:
- 既定のCADを有する患者のMIまたは死亡のリスクに対する病原体負荷の影響を評価する.
- 特定の病原体または全体的な病原体負荷が心血管疾患の有害事象を予測するかどうかを判断する.
主な方法:
- 890人のCAD患者を対象とした前向きな研究.
- 様々な病原体 (CMV,HAV,HSV1,HSV2,C.pneumoniae,H.pylori) に対するIgG抗体とC反応性タンパク質 (CRP) のレベルを評価した.
- 患者さんを平均3年間追跡して,心筋梗塞や死亡を記録した.
主要な成果:
- CMV,HAV,HSV1およびHSV2に対する抗体のより高い罹患率は,後にMIまたは死亡を経験した患者で観察されました.
- 病原体負荷の増加は,MIまたは死亡リスクの投与反応の増加と有意に関連していました.
- 心臓発作または死亡の調整された相対リスクは,CRPレベルとは無関係に,CMV,HAV,HSV2感染症において上昇した.
結論:
- 感染症は,発作性心筋梗塞またはCAD患者の死亡において重要な役割を果たします.
- 感染がもたらすリスクは,病原体全体の負荷と独立して関係しています.
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