アルドステロンの産生は,ヒトの不全した心室で活性化されます
Y Mizuno1, M Yoshimura, H Yasue
1Division of Cardiology, Kumamoto Aging Research Institute, Yamamuro, Kumamoto City 860-8518, Japan.
Circulation
|January 4, 2001
まとめ
アルドステロン,アンジオテンシン変換酵素,およびBNPは,衰弱している人間の心臓で生成されます. 彼らのレベルは,左心室機能不全の重症度に応じて増加し,心臓そのものの内部での局所的生産を示します.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 分子生物学は分子生物学である.
背景:
- 最近の研究では,動物の腎上腺外アルドステロン生成が示唆されています.
- アルドステロン合成のための人間の心臓の能力は,ほとんど未知のままです.
研究 の 目的:
- 人間の心臓内におけるアルドステロン生成の存在と重要性を調査する.
- 心臓アルドステロンのレベルと心不全のマーカーを相関させるため.
主な方法:
- 血アルドステロン,BNP,およびACEの測定 前腹腔間静脈,冠状動脈鼻腔,大動脈の根.
- 左心室内静脈機能不全 (LVSD),左心室内静脈機能不全 (LVDD),および健康な対照群におけるこれらのレベルを比較した.
主要な成果:
- 心臓静脈 (AIV,CS) のアルドステロンの濃度は,LVSDとLVDDの両グループにおいて,大動脈と比較して,著しく高かった.
- 機能不全のグループでは,心臓静脈と大動脈の間で,ACE活性とBNPレベルが上昇したことも観察されました.
- 心臓アルドステロンとBNPレベルは,LVEDPと陽性に関連し,LVSD患者のLVエジェクション分数と陰性に関連した.
結論:
- アルドステロン,ACE,BNPの産生は,衰えつつある人間の心室で活性化されます.
- この活性化の程度は,心不全の重さに比例する.
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