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Updated: May 1, 2026

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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結晶構造と,その効果体であるフォスホイノシチド3-キナーゼガンマにRas結合の機能分析

M E Pacold1, S Suire, O Perisic

  • 1MRC Laboratory of Molecular Biology Hills Road CB2 2QH, Cambridge, United Kingdom.

Cell
|January 4, 2001
PubMed
まとめ

ラスタンパク質は,がん細胞の生存に不可欠なフォスホイノシチド3キナーゼガンマ (PI3Kgamma) を直接活性化します. 構造分析は,この活性化に不可欠な特定の結合相互作用を明らかにし,新しい治療標的を提供している.

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