Rhesus猿の前頭前脳と下頭皮質と前頭皮質と頭皮質と頭皮質と頭皮質と頭皮質と頭皮質と頭皮質との接続

J Kievit, H G Kuypers

Science (New York, N.Y.)

|February 21, 1975

まとめ

研究者は, rhesus猿のヒンズラペロキシデスを用いて神経経路を追跡した. 研究結果は,前頭脳の基礎部から前頭皮質と頭皮質への直接的なつながりを明らかにし,感情と動機付けに影響を与えています.

科学分野:

神経科学は神経科学である.
靈長類の研究は,霊長類の研究である.
コルティカル・コネクティビティとは

背景:

感情とモチベーションの神経回路を理解することは極めて重要です.
基礎前脳は,これらの機能において重要な役割を果たします.
基礎前頭脳からの直接的な皮質の投影は,まだ完全に理解されていません.

研究の目的:

前頭皮質と頭頂皮質との直接的なアフェレント接続を調査する.
感情とモチベーションに影響を与える神経経路の起源を特定する.

主な方法:

ホーラーラディッシュペロキシダース (HRP) 酵素は,前頭皮質と頭皮質の特定の領域にステレオタクシー的に注入されました.
HRPの逆行性軸索輸送は,発射ニューロンを特定するために分析されました.
実験は17匹の成人のレサス猿で行われた.

主要な成果:

HRPの逆行輸送は, substantia innominata, hypothalamus, thalamusにあるニューロンで観察されました.
これらの結果は,これらの基礎前頭脳の領域から研究された皮質領域への直接的なアフェレント繊維の投影を確認しています.
主要な辺縁基礎前頭脳の領域である substantia innominataと hypothalamusは,皮質に投影しています.

結論:

前頭皮質と頭頭皮質は,辺縁基礎前頭脳の構造から直接の神経入力を受けます.
これらの接続は,感情やモチベーションが皮質機能に及ぼす影響を媒介する可能性がある.
この研究は,脳の感情的および動機付け回路における重要な経路を明らかにしています.

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