クラミジア・トラホマティスの血清型と子宮頸部状細胞癌の発症リスク
T Anttila1, P Saikku, P Koskela
1Department of Obstetrics and Gynecology, University of Helsinki, Haartmaninkatu 2, 00290 Helsinki, Finland.
JAMA
|January 10, 2001
まとめ
Chlamydia trachomatisの血清型Gは,子宮頸部状細胞癌のリスクを大幅に増加させます. 複数の血清型の暴露は,このリスクをさらに高め,クラミジア・トラホマティス感染と子宮頸がんとの関連性を強化します.
科学分野:
- 婦人科腫瘍学 婦人科腫瘍学
- 感染症疫学 感染症疫学
- がん研究 がん研究
背景:
- ヒューマン・パピローマウイルス (HPV) は,子宮頸がんの既知の原因である.
- クラミジア・トラホマティス (C. trachomatis) 感染症は,子宮頸部状細胞癌 (SCC) のリスクの増加とも関連しているが,血清型の特異性は不明である.
研究 の 目的:
- 特定のC. trachomatisの血清型と子宮頸部SCCの発生との関連を調査する.
- 子宮頸部SCCのリスクがC. trachomatisの血清型によって異なるかどうかを判断する.
主な方法:
- フィンランド,ノルウェー,スウェーデンの53万人の女性から採取した血清バンクサンプルを用いて,縦断的なケース・コントロール研究が行われました.
- この研究では,侵襲性子宮頸SCCを発症した128人の女性と,症例ごとに3人の対照群を対象に,国家がん登録簿にリンクされたデータを使用した.
- リスクは,C.トラホマチス10型血清型に対するIgG抗体,HPV型16,18,33型および血清コチニン濃度の調整により評価されました.
主要な成果:
- C. trachomatisの血清型Gは,SCCと最も強い関連性を示した (調整されたOR,6.6).
- 血清タイプI (OR,3.8) とD (OR,2.7) も,SCCのリスクの増加と関連していました.
- 複数のC. trachomatis血清型への曝露は,SCCの調整されたオッズ比率を大幅に増加させた (P<.001 for trend).
結論:
- C. trachomatisの血清型Gは,その後の子宮頸部SCC発症と最も強く関連しています.
- 異なるC. trachomatisの血清型への曝露の増加は,子宮頸部SCCのリスクを高めます.
- これらの発見は,過去のC. trachomatis感染と子宮頸部SCCとの関連性を強化しています.
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