成長ホルモンの欠乏症における異常な血管反応性

B Capaldo¹, V Guardasole, F Pardo

¹Departments of Internal Medicine and Cardiovascular Sciences and of Endocrinology, University Federico II, Naples, Italy.

Circulation

|February 7, 2001

まとめ

成長ホルモン (GH) 欠乏症は,患者の血管反応性を低下させ,心血管リスクに寄与します. GH補充療法は,正常な血管機能を回復させ,心血管の健康を維持する上でGHの重要な役割を強調します.

科学分野:

心血管生理学心血管の生理学
エンドクリノロジーエンドクリノロジー
血管生物学血管生物学

背景:

成長ホルモン (GH) 欠乏症 (GHD) の患者は,心血管疾患による死亡率の増加に直面しています.
GHDに関連する動脈硬化症における血管反応性の役割は十分に理解されていません.

研究の目的:

幼児期発症のGHD患者の血管機能と反応性を調査する.
GH置換療法がGHD患者における血管機能を正常化するかどうかを判断する.

主な方法:

ストレインゲージ・プレチスモグラフィーは,前腕の血管拡張器に対する血流反応を測定するために使用されました.
血管の反応性は,エンドセリウム依存 (アセチルコリン) と独立 (ナトリウムニトロプルーシド) 剤を用いて評価された.
前腕のニートリートとcGMPの放出,およびイシュケミアのピーク高血圧反応が測定されました.

主要な成果:

未治療のGHD患者では,アセチルコリンとナトリウムニトロプルーシドに対する前腕の血流反応が著しく低下しました.
アセチルコリン刺激中のナイトライトとcGMPの放出は,未治療のGHD患者で低かった.
GH補充療法は,GHD患者における血管反応性と高血圧性 ischemiaへの応答を正常化しました.

結論:

GHは,ヒトの正常な血管機能を維持するために不可欠です.
GHDにおける血管反応性の低下は,心血管疾患のリスクの増加に寄与する.
GH治療は,GHD患者の血管機能を回復することができます.

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