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Updated: May 5, 2026

Generation of Human CD40-activated B cells
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CD45の阻害基の不活性化点変異はリンパ増殖と自己免疫を引き起こす

R Majeti1, Z Xu, T G Parslow

  • 1Department of Medicine, University of California-San Francisco, San Francisco, CA 94143, USA.

Cell
|February 13, 2001
PubMed
まとめ

マウスにおけるCD45 (タンパク質チロシン・フォスファタゼ) の重要な調節部分の不活性化は,重度の自己免疫疾患と死亡を引き起こした. これは,CD45の調節が,免疫系の過剰活性化を防ぐ上で果たす重要な役割を強調しています.

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