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Bビタミンでアテロゲン性ダイエットを補充することは,猿の動脈硬化症や血管機能不全を予防しません
S R Lentz1, D J Piegors, M R Malinow
1Veterans Affairs Medical Center, Departments of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA. steven-lentz@uiowa.edu
Circulation
|February 22, 2001
まとめ
ビタミンBサプリメントは,サルにおける高濃度のホモシステインを効果的に予防します. しかし,高コレステロールでも,血管機能障害や動脈硬化を防ぐことはできません.
科学分野:
- 心血管研究 循環器科の研究
- 栄養科学とは,栄養科学である.
- 血管生物学 血管生物学
背景:
- ハイパーホモキステン血症は,動脈硬化および血栓性血管疾患の既知の危険因子です.
- ダイエットによるビタミンBサプリメントは,ハイパーホモシスタイン血症の管理のための潜在的な戦略です.
- 血管疾患の予防におけるビタミンBの臨床的有効性は,まだ証明されていない.
研究 の 目的:
- ビタミンBのサプリメントが,高ホモシスタイン血症,血管機能障害,動脈硬化症を予防するかどうかを,動脈硬化ダイエット中のサルで調査する.
- 類人猿のモデルで血管の健康マーカーにビタミンBの影響を決定する.
- ダイエットによる血管病変の軽減にビタミンBの充足度を評価する.
主な方法:
- 類人猿は,アテロゲン的な食事を与えられ,一グループはビタミンBサプリメント (葉酸,B12,B6) を摂取し,対照群はサプリメントを受けなかった.
- 血ホモシステインと血清コレステロールのレベルは17ヶ月後に測定されました.
- 血管機能は,内皮に依存する血管拡張剤に対する反応を測定することによって,in vivoおよびex vivoで評価されました.
- 大動脈の動脈硬化病変の発達,特に内臓の加厚は,大動脈で評価されました.
主要な成果:
- ビタミンBサプリメントは,プラズマホモシステイン濃度の上昇を成功裏に防止しました.
- 補給されたグループも,補給されていないグループも,血清コレステロールの有意な増加を示しました.
- 血管拡張反応と抗凝固剤反応で評価された血管機能障害は,両方のグループで同様に低下しました.
- ビタミン補給は,頸動脈や動脈の内密の加厚を防ぐことはできませんでした.
結論:
- 食事中のビタミンBは,この霊長類のモデルにおいて,ハイパーホモシスタイン血症を効果的に予防します.
- ビタミンBサプリメントのみは,顕著な高コレステロール血症の存在において,血管機能障害と動脈硬化症を予防するのに不十分です.
- これらの発見は,ホモシステイン,コレステロール,および血管の健康との複雑な相互作用を強調し,ビタミンBが食事による血管疾患を予防する単独の解決策ではないことを示唆しています.
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