Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Induced-fit Model01:13

Induced-fit Model

Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical characteristics of...
Cofactors and Coenzymes01:27

Cofactors and Coenzymes

Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic ions and coenzymes are non-protein organic molecules. Both of these types of helper molecule can be tightly bound to the enzyme or bound only when the substrate binds.
Enzymes02:34

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...
Cofactors and Coenzymes01:24

Cofactors and Coenzymes

Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via ionic interactions or acid-base reactions. However, amino acids cannot catalyze oxidation-reduction and group transfer reactions and need to be aided by non-protein components called cofactors. Cofactors are also referred to as the chemical teeth of an enzyme.
Cofactors can be metallic ions or organic molecules called coenzymes. These types of helper...
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Novel therapies for coeliac disease.

Journal of internal medicine·2011
Same author

Accurate, conformation-dependent predictions of solvent effects on protein ionization constants.

Proceedings of the National Academy of Sciences of the United States of America·2007
Same author

Prolyl endopeptidases.

Cellular and molecular life sciences : CMLS·2006
Same author

Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy.

Oncogene·2006
Same author

Production of ansamycin polyketide precursors in Escherichia coli.

The Journal of antibiotics·2006
Same author

Process development and metabolic engineering for the overproduction of natural and unnatural polyketides.

Advances in biochemical engineering/biotechnology·2002
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026
Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: May 12, 2026

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System
08:10

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

モジュラー酵素は,モジュラー酵素である.

C Khosla1, P B Harbury

  • 1Department of Chemistry, Stanford University, California 94305, USA. ck.chemeng.stanford.edu

Nature
|February 24, 2001
PubMed
まとめ
この要約は機械生成です。

分離可能な酵素やマルチ酵素系を含むモジュール式生物触媒は,生物学において極めて重要です. バイオカタリシスにおけるそれらの認識は,合成化学とプロセス化学のための新しい機会を提供します.

さらに関連する動画

Modeling an Enzyme Active Site using Molecular Visualization Freeware
14:37

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

関連する実験動画

Last Updated: May 12, 2026

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System
08:10

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System

Published on: August 8, 2016

Modeling an Enzyme Active Site using Molecular Visualization Freeware
14:37

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

科学分野:

  • バイオカタリシス バイオカタリシス
  • 分子生物学は分子生物学である.
  • 合成化学 合成化学とは

背景:

  • モジュラー型マクロ分子装置は,生物系において一般的です.
  • バイオカタリシスにおけるこれらのモジュール構造の役割は,しばしば見過ごされています.
  • モジュール性の理解は,酵素アプリケーションの進歩の鍵です.

研究 の 目的:

  • モジュール式生物触媒の識別と分類.
  • バイオカタリシスにおけるモジュール式バイオカタリシストの重要性を強調する.
  • 合成化学およびプロセス化学におけるモジュール式生物触媒の潜在的な影響を調査する.

主な方法:

  • モジュール式生物触媒の分類は,主に3つのグループに分類されます.
  • モジュール性に関連する酵素構造と機能の分析.
  • モジュール式生物触媒に関する既存の文献のレビュー.

主要な成果:

  • モジュール式生物触媒の3つのクラスを特定した:分離可能な触媒/特異性酵素,モジュール式結合部位を持つ多基板酵素,代謝経路のための多酵素系.
  • バイオカタリシスにおけるモジュール性の普及と重要性を実証した.
  • 多酵素系を用いたプログラム可能な代謝経路の可能性を強調した.

結論:

  • モジュール式生物触媒は,生物触媒の重要で過小評価されているクラスです.
  • 特定されたクラスは,モジュール式バイオカタリシスを理解するための枠組みを提供します.
  • ポストゲノム時代は,化学におけるモジュール式生物触媒の発見と利用のための新しい道を開く.