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Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Bioreactor Controls-II01:18

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Designing Growth Media for Bioreactors01:30

Designing Growth Media for Bioreactors

Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Biofuels01:25

Biofuels

The microbial conversion of organic matter into biofuels holds potential as a renewable energy source. Among biofuel sources, microalgae are recognized as a highly efficient and adaptable feedstock for biodiesel production, owing to their rapid biomass accumulation, elevated lipid productivity, and capacity to proliferate in diverse aquatic systems, including freshwater, marine, and wastewater habitats. Unlike terrestrial crops, microalgae do not compete for land and can achieve significantly...

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関連する実験動画

Updated: May 20, 2026

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
09:27

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

Published on: April 22, 2016

生物触媒設計における組み合わせと計算上の課題

F H Arnold1

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA.

Nature
|February 24, 2001
PubMed
まとめ
この要約は機械生成です。

自然 自然 自然 自然です.

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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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関連する実験動画

Last Updated: May 20, 2026

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability
09:27

Immobilization of Multi-biocatalysts in Alginate Beads for Cofactor Regeneration and Improved Reusability

Published on: April 22, 2016

Biogas Purification through the use of a Microalgae-Bacterial System in Semi-Industrial High Rate Algal Ponds
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Biogas Purification through the use of a Microalgae-Bacterial System in Semi-Industrial High Rate Algal Ponds

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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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科学分野:

  • バイオカタリシスと酵素工学は,技術的な応用のためのものです.
  • 合成生物学と代謝工学. 合成生物学と代謝工学.
  • 計算化学とタンパク質設計.

背景:

  • 自然の触媒 (酵素) は生命にとって非常に効果的ですが,しばしば産業技術には適しません.
  • 自然触媒の調整や再設計は,その技術的影響にとって極めて重要です.
  • 酵素最適化のための既存の方法は急速に進歩しています.

研究 の 目的:

  • テクノロジーにおけるバイオカタリシスの可能性を探求する.
  • 酵素工学とコンピューティング・メソッドの重要性を強調する.
  • 様々な産業のカタリスト開発の将来を概説する.

主な方法:

  • 酵素の選択性と活性を微調整するための実験室での進化.
  • 複雑な生物学的問題に対する組み合わせ方法の開発.
  • 触媒設計のための計算方法の進歩.

主要な成果:

  • 組み合わせによる方法は,新しい生物合成経路の創出において有望であることが示されています.
  • 計算によるアプローチは急速に改善されています.
  • 実験室の進化とコンピューティング・メソッドの統合が鍵となる.

結論:

  • 実験室での進化と計算によるアプローチを組み合わせることで,効率的な触媒が得られます.
  • この統合は,製薬,食品,化学産業に利益をもたらすだろう.
  • 再生可能エネルギーと化学製品生産の新たな機会が生まれます.