転写活性化剤BmrRの結晶構造は,DNAと薬物に結合している

E E Heldwein1, R G Brennan

  • 1Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201-3098, USA.

Nature
|February 24, 2001
PubMed
まとめ

バクテリアの多剤耐性症は,しばしば薬物の放出ポンプによって引き起こされます. この研究では,BmrR (転写レギュレータ) が,抵抗を制御する新しいメカニズムであるDNA塩基対の断裂とスライドによってトランスポーター遺伝子発現を活性化する方法が明らかにされています.

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