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関連する実験動画

Updated: Jul 12, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

脳ドーパミンと肥満

G J Wang1, N D Volkow, J Logan

  • 1Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA. giwang@bnl.gov

Lancet (London, England)
|February 24, 2001
PubMed
まとめ

肥満者はドーパミンD2受容体の利用度が低く,BMIが高くなる. このドーパミンの欠乏は,報酬回路の活性化が低下した補償メカニズムとして過食を誘発する可能性があります.

科学分野:

  • 神経科学は神経科学である.
  • メタボリック障害 メタボリック障害
  • 依存症の研究 依存症の研究

背景:

  • 病理的な過食と肥満のメカニズムは十分に理解されていません.
  • ドーパミンの神経伝達が食物報酬に関与しています.
  • 肥満におけるドーパミンD2受容体の可用性を調査することは極めて重要です.

研究 の 目的:

  • 肥満者における異常な脳ドーパミン活動に関する仮説を検証する.
  • 肥満患者および対照群の脳におけるドーパミンD2受容体の可用性を測定する.

主な方法:

  • [C-11]ラクロプリドによるポジトロン放出トモグラフィ (PET) を用いて,ドーパミンD2受容体の可用性を測定した.
  • ドーパミンD2受容体の可用性は,線状体におけるBmax/Kdを使用して定量化されました.
  • 脳のグルコース代謝は,2-デオキシ-2[18F]フッ素-D-グルコース (FDG) を使用して評価されました.

主要な成果:

  • 肥満の個人は,対照群と比較して,ストライタルドーパミンD2受容体の可用性が著しく低下しました.
  • 体重指数 (BMI) と,肥満者におけるドーパミンD2受容体の可用性との間に負の相関が認められた.
  • グループ間の全脳またはストライアタル代謝の違いは観察されず,システマティックな放射性トレーサーの配送問題を排除しました.

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Intermittent Binge-Intake Model in Mice
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Intermittent Binge-Intake Model in Mice

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Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

関連する実験動画

Last Updated: Jul 12, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Intermittent Binge-Intake Model in Mice
05:15

Intermittent Binge-Intake Model in Mice

Published on: January 10, 2025

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

結論:

  • 肥満者におけるドーパミンD2受容体の可用性の低下は,BMIに比例する.
  • ドーパミンの欠乏は,報酬回路の活性化の低下を補うために,病的な食べ方を永続化させる可能性があります.
  • ドーパミン機能を標的とする治療戦略は,肥満の治療に役立ちます.