関連する実験動画
Updated: Jun 29, 2026
07:59
Folding and Characterization of a Bio-responsive Robot from DNA Origami
Published on: December 3, 2015
境界形成を媒介するノッチを持つスカブロス複合体
P A Powell1, C Wesley, S Spencer
1Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nature
|February 24, 2001
まとめ
Scabrousタンパク質は,ノッチ受容体を安定させ,プロニューラルクラスタの境界を鋭くする. このメカニズムは,ドロソフィラの網膜の発達中に単一の先駆者ニューロンの正しい形成を保証します.
科学分野:
- 発達生物学 発達生物学とは
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
背景:
- エピテリアのパターン形成はよくわかっていない.
- アトナル発現によって特徴づけられるプロニュラルクラスターは,ドロソフィラ網膜の発達中の初期のパターン要素である.
- ノッチ・シグナリングは,アトナル表現の確立とパターニングに不可欠です.
研究 の 目的:
- Notchシグナル伝達とプロニューラルクラスター形成におけるScabrousの役割を調査する.
- ドロソフィラの網膜におけるパターンの鋭化に根本的な分子メカニズムを解明する.
主な方法:
- ドロソフィラ・メラノガスターの体内研究.
- タンパク質の相互作用を分析するための生化学分析.
- アトナル発現とプロニューラルクラスター境界の分析.
主要な成果:
- 分泌されるScabrousタンパク質は,Notch受容体と結合する.
- Scabrousは,Notchタンパク質を細胞表面で安定させています.
- この相互作用により,プロニューラルクラスタの境界が鋭くなります.
- 単一の先駆者ニューロンの形成を保証する.
結論:
- 甲状腺媒介によるノッチ活動の安定化は,発達中の網膜における正確なパターン形成に不可欠である.
- 発見は,発達過程が鋭い境界線と単細胞の運命をどのように確立するかについての洞察を提供します.
関連する概念動画
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:03Anchoring Junctions
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
01:21Boundary Conditions: Lossless Lines
Consider a single-phase, two-wire, lossless transmission line terminated by an impedance at the receiving end and a source with Thevenin voltage and impedance at the sending end. The line, with length, has a surge impedance and wave velocity determined by the line's inductance and capacitance.
At the receiving end, the boundary condition states that the voltage equals the product of the receiving-end impedance and current. This relationship is expressed as a function of the incident and...
At the receiving end, the boundary condition states that the voltage equals the product of the receiving-end impedance and current. This relationship is expressed as a function of the incident and...