基本的震における震に関連した皮質活動
B Hellwig1, S Häussler, B Schelter
1Neurologische Universitätsklinik, Freiburg, Germany.
Lancet (London, England)
|March 7, 2001
まとめ
電気脳図 (EEG) は,以前の磁気脳図 (MEG) 研究とは異なり,本質的な震えに関連した感覚運動皮質の活動を成功裏に検出しました. これは,センソモーター皮質が本質的な震え発生に役割を果たしていることを示唆しています.
科学分野:
- 神経科学は神経科学である.
- 臨床神経学 臨床神経学
背景:
- 感覚運動皮質の震動に関連した活動は,パーキンソン病期の休息震で知られており,磁気脳図 (MEG) と電気脳図 (EEG) で研究されています.
- 以前のMEG研究では,本質的震動における皮質の関与を検出できませんでした.
- この研究では,本質的な震えと強化された生理学的震えにおいて,震えに関連した皮質の活動を検出するEEGの能力を調査しました.
研究 の 目的:
- エレクトロエンケファログラフィー (EEG) によって,本質的な震え (ET) または生理学的震え (EPT) が強化された患者の震えに関連した皮質の活動を特定できるかどうかを判断する.
- 以前の磁気脳図 (MEG) とのEEGの結果を比較すると,本質的な震えが起こります.
主な方法:
- 7人のETと3人のEPT患者の手首の伸縮筋と屈曲筋からの高解像度EEGと電動肌図 (EMG) の同時記録.
- 患者は震えを活性化するために,片面の姿勢的な手首拡張を行いました.
- 矯正震動のEMGとEEG信号の間の相関性を推定する.
主要な成果:
- EMGとEEGの間の重要な震動周波数相関は,9つのETアームの5つで発見されました.
- アイソコーレンスマップは,対側感知運動皮質に最大コヒーレンスを局所化しました.
- EPT患者では,一貫した有意な筋皮相連性は検出されなかった.
結論:
- 同時に行われたEEG-EMGの記録は,本質的震における震周波数において,有意な筋皮質相関性を示しています.
- この発見は,以前のMEG研究と対照的であり,ETにおける皮質の関与を検出する際にEEGがより敏感であることを示唆しています.
- 結果は,パーキンソン病の休息震えに類似した,本質的な震えの発生にセンソモーター皮質の関与を示しています.
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