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炎症と癌: ヴィルチョウに戻る
1ICRF Translational Oncology Laboratory, St Bartholomew's and Royal London School of Medicine and Dentistry, UK. f.balkwill@icrf.icnet.uk
Lancet (London, England)
|March 7, 2001
まとめ
癌の進行は,炎症や傷の治癒に類似しています. 炎症経路とサイトカインをターゲットにすることは,がんの予防と治療に有望であり,新しい治療戦略を提供している.
科学分野:
- 腫瘍学 腫瘍学
- 免疫学 免疫学とは
- 炎症研究 炎症の研究
背景:
- 癌の反応メカニズムは,炎症と傷の治癒と重なり合っている.
- 腫瘍内の炎症性細胞とサイトカインは,がんの成長と免疫抑制を促進する可能性があります.
- 炎症性サイトカイン遺伝子の遺伝的変異は,がんの感受性および重症度に影響を与える可能性があります.
研究 の 目的:
- 癌と炎症の間の複雑な関連をレビューする.
- 癌の予防と治療戦略に対するこれらのつながりの意味について議論する.
- 悪性疾患におけるサイトカインとケモカイン経路を標的とするための論理的根拠を提供すること.
主な方法:
- 癌,炎症,傷の治癒の関係に関する文献レビュー.
- 腫瘍の進行における炎症性細胞とサイトカインの役割の分析.
- 炎症性サイトカイン遺伝子における遺伝的ポリモルフィズムの研究.
- サイトカイン/ケモカイン阻害および抗炎症薬を含む治療戦略のレビュー.
主要な成果:
- 腫瘍における炎症媒介物質は,しばしば腫瘍の成長,進行,免疫抑制を促進する.
- 炎症性サイトカインの抑制は,実験的な癌の発症を防ぐのに有効であることが示されています.
- サイトカインとケモカインのアンタゴニストは,腫瘍死滅因子アンタゴニストと同様に,関連する疾患において臨床的有効性を示しています.
結論:
- 炎症は,がんの発生と進行を促す"燃料"として機能する.
- ブロックを介してサイトカインとケモカインネットワークをターゲットにすることは,がんの治療と予防のための実行可能な戦略です.
- 非ステロイド性抗炎症薬のさらなる調査は,がんの化学予防と治療のために正当化されています.
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