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トロンボモジュリンAla455Valポリモルフィズムと冠動脈疾患のリスク
1Vascular Biology Research Center and Division of Hematology, Department of Internal Medicine, The University of Texas-Houston Health Science Center, Houston, TX 77030, USA.
Circulation
|March 14, 2001
まとめ
トロンボモジュリンA455V遺伝子変異は,黒人個体において冠動脈疾患 (CHD) の発症リスクを6倍以上増加させる. この遺伝的要因は,白人の集団におけるCHDリスクに大きな影響を与えない.
科学分野:
- 心血管の遺伝学について
- 分子伝染病学 分子伝染病学
背景:
- トロンボモジュリン (TM) は,内皮細胞に発現する血管保護に不可欠です.
- 既知のTMポリモルフィズム (A455V) は,急性心筋梗塞と関連している.
- 冠動脈性心疾患 (CHD) リスクに対するこのTMポリモルフィズムの予測価値は依然として不確実です.
研究 の 目的:
- トロンボモジュリンA455V単核酸ポリモルフィズムが冠動脈性心疾患 (CHD) の発症リスクを予測するかどうかを調査する.
主な方法:
- 大規模なコホート研究では,5年間の追跡期間中にインシデントCHD症例を特定しました.
- TM-455のゲノタイプは,CHD症例と,人種差異 (黒人と白人の集団) を分析した基準サンプルを決定しました.
- 年齢,性別,およびその他のCHDリスク要因に調整された重量比例リスク回帰分析が採用されました.
主要な成果:
- AA遺伝子型は非症例では症例より一般的であった (P=0.016).
- AA遺伝子型頻度は,非症例と比較して黒人の症例において有意に低かった (P=0.018).
- Vアレルは,黒人個体では6.1倍に増加した心血管疾患のリスク (リスク比6.1,95%CI1.7-22.9),白人個体では有意に増加しなかった.
結論:
- トロンボモジュリンA455Vのポリモルフィズムが,黒人集団における冠動脈疾患 (CHD) のリスクを予測する要因として機能しています.
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