多囊性卵巣症候群は,内皮機能不全と関連しています
G Paradisi1, H O Steinberg, A Hempfling
1Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202-5111, USA.
Circulation
|March 14, 2001
まとめ
ポリキスティック卵巣症候群 (PCOS) の女性は,内皮機能障害とインスリン血管拡張の障害を示し,高いアンドロゲンとインスリン抵抗性に関連し,心血管疾患のリスクを高めます.
科学分野:
- 心血管内分泌学 心血管内分泌学
- メタボリックシンドロームの研究
- 血管生物学 血管生物学とは
背景:
- 内皮機能不全は,インスリン抵抗性や肥満に関連する心血管疾患の危険因子です.
- 多発性卵巣症候群 (PCOS) は,ハイパーアンドロゲニズム,インスリン抵抗性,およびマクロ血管疾患のリスクの増加と関連しています.
研究 の 目的:
- PCOSの女性における内皮機能の調査.
- PCOSにおける内皮機能不全が代謝またはホルモン要因と関連しているかどうかを判断する.
主な方法:
- 内皮に依存する血管拡張剤であるメタコリン塩化物 (MCh) に対する足の血流 (LBF) 反応を研究した.
- エウグライセミック・ハイパーインスリン血症に対するLBF反応の評価.
- PCOSを持つ12人の肥満女性と13人の健康な肥満女性を比較した.
主要な成果:
- PCOSグループは,OBWと比較して,MChに対するLBF応答が50%低いことを示しました.
- 超インスリン血症は,PCOSではLBFを30%増加させ,OBWでは60%増加させた.
- MChに対する最大LBF反応は,自由テストステロンレベルと逆相関していた (r=-0.52,P:<0.007).
結論:
- PCOSは,内皮機能障害とインスリン血管拡張障害によって特徴付けられます.
- PCOSにおける内皮機能不全は,アンドロゲンとインスリン抵抗性の上昇と関連しています.
- この発見は,PCOSの女性におけるマクロ血管疾患のリスクの増加を説明する可能性がある.
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