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生殖期と閉経後の女性の認知症のリスク
M I Geerlings1, A Ruitenberg, J C Witteman
1Department of Epidemiology and Biostatistics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, the Netherlands. geerlings@epib.fgg.eur.nl
JAMA
|March 23, 2001
まとめ
自然閉経の女性の生殖期間の延長は,認知症とアルツハイマー病 (AD) のリスクの増加と関連していました. この発見は,より長いエストロゲン被曝が認知症のリスクを減らすという仮説を支持しません.
科学分野:
- 神経科学は神経科学である.
- エピデミオロジー エピデミオロジー
- 生殖内分泌学 生殖内分泌学
背景:
- 外因的なエストロゲンの使用は,閉経後の女性の認知症リスクの低下と関連しています.
- 認知症のリスクに対する長期的な内生性エストロゲン被曝の影響は,ほとんど研究されていない.
研究 の 目的:
- 内生性エストロゲン被曝の代理として,より長い生殖期間の関連性を調査し,自然閉経を経験した女性の認知症とアルツハイマー病 (AD) のリスクを調べる.
主な方法:
- ロッテルダム研究 (The Rotterdam Study) は,オランダにおける将来的な人口ベースのコホート研究である.
- 初期認知症のない55歳以上の女性3601人を含め,初潮および更年期における年齢を評価した.
- 認知症とADの発生率はモニタリングされ,生殖期間の長さの四分位数で比較されました.
主要な成果:
- 21,046人年において,199人の女性が認知症を発症した (ADは159人).
- 共同変数を調整した後,自然閉経とより長い生殖期間 (>39年) を有する女性は,認知症 (調整RR, 1.78) とAD (調整RR, 1.51) のリスクが増加しました.
- この増加したリスクは,APOE ε4キャリアにおいて最も顕著であった.
結論:
- 研究結果は,より長い生殖期が自然閉経の女性の認知症から保護するという仮説を支持しません.
- 逆に,より長い生殖期は,認知症とADのリスクの増加と関連している可能性があります.
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