腹部大動脈の石灰鉱は,血管疾患と死亡率の重要な予測因子です
P W Wilson1, L I Kauppila, C J O'Donnell
1From the NHLBI's Framingham Heart Study and Boston University School of Medicine, Framingham, Massachusetts, USA.
Circulation
|March 21, 2001
まとめ
腰部X線で検出された腹動脈カルシウム (AAC) 堆積は,心血管疾患 (CVD) のリスクを予測します. AAC濃度の上昇は,冠動脈疾患,CVD,および死亡率の上昇と関連しており,リスク評価におけるその価値を強調しています.
科学分野:
- 心血管疾患の疫学について
- 放射線学 放射線学
- 血管疾患の研究について
背景:
- 心血管疾患 (CVD) は,世界中で死亡の主な原因であり続けています.
- CVDの予測マーカーは,早期介入とリスクの階層化において極めて重要です.
- 長期のCVD予測における腹動脈カルシフ堆積の役割については,さらなる調査が必要である.
研究 の 目的:
- 腹部大動脈カルシウム (AAC) が横側腰部放射線写真で検出され,発症冠動脈疾患 (CHD),CVD,CVD死亡率の予測因子として評価する.
- 大規模なコホートで,AACの異なる度合いと長期的な血管疾患の発生率との関連性を評価する.
- AACが血管疾患と死亡率の独立した予測因子であるかどうかを判断する.
主な方法:
- 1967年から1989年まで,男性1049人と女性1466人 (平均年齢61歳) のコホートを追跡した.
- 側腰部のX線画像は,検証された0-24ポイントスケールを使用して,前後腹部大動脈 (AAC) のカルシフ堆積物を分析しました.
- 比率的な危険物流的回帰モデルを使用して,AACテルティールとインシデントCHD,CVD,CVDの死亡率との関連性を評価し,複数の危険因子に調整しました.
主要な成果:
- AACのより高い階層は,最も低い階層と比較して,男性と女性の両方でCVDの相対リスクが著しく増加した.
- 多変量分析は,AACがインシデントCHD,CVD,CVD死亡率の有意な予測要因であることを示しました.
- 同様の関連性は,CHDとCVDの死亡率でも観察され,異なる血管端点における一貫した予測値を示唆しました.
結論:
- 腹部大動脈カルシウム (AAC) の堆積は,横側腰部放射線写真で識別され,亜臨床性動脈硬化症のマーカーとして機能します.
- AACは,その後の血管疾患および死亡率の独立した予測因子です.
- AACの通常の放射線診断は,将来の心血管疾患のリスクが高い個人を特定するのに役立ちます.
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