妊産婦の内皮機能障害と妊娠前出血症の関連性
J C Chambers1, L Fusi, I S Malik
1National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, England. j.kooner@ic.ac.uk
JAMA
|April 13, 2001
まとめ
前出産前出産歴のある女性は,産後の内皮機能障害を示し,酸化ストレスに関連しています. アスコルビック酸による抗酸化剤治療は血管機能を改善し,これらの女性の治療目標を示唆しています.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 心血管科学の研究について
- 血管生物学 血管生物学
背景:
- 妊産前症候群は,母体の血管内皮を損傷させる胎盤の要因と関連しています.
- 妊娠に限られた以前の研究では,内皮機能不全の母体対胎盤のメカニズムを隔離することができなかった.
研究 の 目的:
- 妊娠していない女性の内皮機能を調査する. 妊娠前のプレエクラムプシア.
- 酸化ストレスがこれらの女性の内皮機能不全を媒介するかどうかを判断する.
主な方法:
- 症例対照試験では,先発性出産前症候群の女性113人と48人の対照群で,内皮機能 (フローメディエイトおよびグリセリル三酸塩誘発の膨張) を比較した.
- 酸化ストレスを評価するために,アスコルビック酸の静脈内投与後に測定を繰り返しました.
主要な成果:
- 前出産前出産症の女性は,対照群と比較して,フローメディエイトされた膨張が著しく低下した.
- 内皮の独立した膨張は,グループごとに類似していました.
- アスコルビック酸は,以前に出産前症候群の女性では,フローメディエーションによる膨張を改善したが,対照群ではそうではなかった.これは酸化ストレスへの関与を示している.
結論:
- 内皮機能不全は,出産後にも,出産前不全歴のある女性において持続する.
- この機能不全は,従来の血管の危険因子では説明できない.
- アスコルビック酸による抗酸化剤療法では,内皮機能障害を逆転させる可能性があることが示されています.
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