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Updated: Apr 16, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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人間の免疫反応を抑制するB7-1/CTLA-4複合体の結晶構造です

C C Stamper1, Y Zhang, J F Tobin

  • 1Departments of Biological Chemistry and Musculoskeletal Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA.

Nature
|March 30, 2001
PubMed
まとめ

免疫調節の分子基礎を理解することは,免疫療法の鍵です. この研究は,CTLA-4/B7-1複合体の結晶構造を明らかにし,これらの分子が安定した,ジッパーのような構造を形成してT細胞の反応を調節する方法を示しています.

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