ATP生成経路の進化における協力と競争
T Pfeiffer1, S Schuster, S Bonhoeffer
1Friedrich Miescher Institute, Post Office Box 2543, CH-4002 Basel, Switzerland., Max Delbrück Center for Molecular Medicine, D-13092 Berlin, Germany.
Science (New York, N.Y.)
|April 3, 2001
まとめ
細胞は,エネルギー生産においてトレードオフに直面しています. 高収量アデノシントリフォスファート (ATP) 生産は,遅いですが,構造化された環境で進化し,多細胞生命への移行を助けることができます.
科学分野:
- バイオケミストリー バイオケミストリー
- 進化生物学の進化生物学について
- システム生物学 システム生物学
背景:
- ヘテロトロフな生物は,アデノシントリフォスファート (ATP) 生産の速度と生産量をバランスをとります.
- このトレードオフは進化的ジレンマを提示しており,より低い収穫量でより速いATP生産が競争上の優位性を与えることができるからです.
- このバランスを理解することは,細胞のエネルギー戦略と進化の移行を理解するために不可欠です.
研究 の 目的:
- ATPの生産速度と収穫量の進化的動態を調査する.
- 高収量ATP生産戦略が進化できる条件を探求する.
- 多細胞性の進化における高ATP生産量の役割を評価する.
主な方法:
- 計算モデルシミュレーションの分析.
- 生化学的観測とデータ解釈.
- 異なる代謝戦略の比較分析.
主要な成果:
- 低率と高収量で特徴づけられるATP生産は,協力的な資源利用として解釈できます.
- このような高利回り戦略は好まれ,空間的に構造化された環境の中で進化することができます.
- 呼吸を通じたATP生成の効率は,初期の多細胞生物の進化の重要な要因であったかもしれない.
結論:
- 高収量ATP生産による共同資源利用は,構造化された集団において進化的に実行可能な戦略である.
- 呼吸によるATPの高い生産性は,単細胞から多細胞生物への進化の飛躍に重要な役割を果たしたと考えられます.
- この研究は,主要な進化的移行のバイオエネルギー的基盤についての洞察を提供します.
関連する概念動画
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01:31ATP Energy Storage and Release
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
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