関連する実験動画

Updated: May 12, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 18, 2011

BACH1はヘリケアゼのような新しいタンパク質で,BRCA1と直接相互作用し,DNA修復機能に貢献します

S B Cantor1, D W Bell, S Ganesan

  • 1The Dana-Farber Cancer Institute and the Harvard, Medical School, Boston, MA 02115, USA.

Cell
|April 13, 2001
PubMed
まとめ

研究者らは,BACH1というDEAHヘリカーゼがBRCA1.1と相互作用することを発見した. この相互作用はDNA修復に不可欠であり,BACH1変異は早期発症の乳がんと関連しており,がんを引き起こす遺伝子でもある可能性を示唆しています.

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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging06:44

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