ランダム化制御試験における盲目化用語に関する医師の解釈と教科書の定義
P J Devereaux1, B J Manns, W A Ghali
1Department of Medicine, McMaster University, 1200 Main St W, Room 2C12, Hamilton, Ontario, Canada L8N 3Z5. philipj@mcmaster.ca
JAMA
|April 20, 2001
まとめ
ランダム化対照試験 (RCT) の単一,二重,三重盲検に関する医師の解釈と教科書の定義は,著しい差異を示しています. 研究の明確性を高めるために,盲目状態に関するより明確な声明が推奨されています.
科学分野:
- 臨床研究方法論 臨床研究方法論
- 根拠に基づいた医学は,証拠に基づいた医療です.
背景:
- 臨床医は,ランダム化比較試験 (RCT) を通常,盲目状態の評価によって評価します.
- 目がくらむための現在の用語 (シングル,ダブル,トリプル) は,さまざまな解釈の対象となります.
研究 の 目的:
- 医師がRCTにおける盲目化用語をどのように解釈するかを決定する.
- シングル,ダブル,トリプルブラインディングの教科書の定義を分析する.
主な方法:
- カナダの3つの大学で実施された観察研究では,カナダの大学で実施された3つの大学で実施された観察研究では,カナダの大学で実施された3つの大学で実施された3つの大学で実施された観察研究では,カナダの大学で実施された3つの大学で実施された3つの大学で実施された
- 91人の内科医師が,失明についての理解に関する調査を完了しました.
- 失明の定義は,1990年以来出版された25冊の教科書から抽出されました.
主要な成果:
- 医者は,それぞれ単一,二重,三重の失明に対して10,17,および15の異なる解釈を提供した.
- 教科書では,各失明レベルに対して5,9,7つの異なる定義が与えられました.
- 医者の解釈と教科書の定義の両方において,特にダブルとトリプルブラインディングにおいて,高い変動が観察されました.
結論:
- 医者の間で,そして医学教科書の中で,盲目化用語の解釈と定義において,重大な不一致が存在します.
- "単一"や"二重"や"三重"といった曖昧な用語は,RCTにおけるすべての関係者の盲目状態を詳細に述べる明示的な記述に置き換えられるべきである.
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