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Updated: May 12, 2026

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
11:19

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses

Published on: February 26, 2011

アミノアシルtRNA合成酵素で,その配列は既知の2つのクラスに適合しない

C Fàbrega1, M A Farrow, B Mukhopadhyay

  • 1The Skaggs Institute for Chemical Biology, The Scripps Research Institute, Beckman Center, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature
|May 3, 2001
PubMed
まとめ

研究者らは,古生物における新しいシステニル転送RNA合成酵素を発見し,既存のタンパク質合成モデルに挑戦した. この古代の酵素にはカノニカルモチーフが欠けていて,本質的なアミノアシレーション反応の進化の経路が異なることを示唆しています.

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Cell-Type Specific Protein Purification and Identification from Complex Tissues Using a Mutant Methionine tRNA Synthetase Mouse Line07:39

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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