関連する実験動画

Updated: Jun 24, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

COP9によるNEDD-CUL1結合裂解の促進は,シグナルソームであるCOP9によって促進される

S Lyapina1, G Cope, A Shevchenko

  • 1Department of Biology, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|May 5, 2001
PubMed
まとめ

COP9シグナルゾーム (CSN) はCUL1と相互作用し,タンパク質の分解を調節する. CSNは,CUL1からNEDD8の除去を促進し,さまざまな細胞プロセスに影響を与えます.

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Quantitative Detection of DNA-Protein Crosslinks and Their Post-Translational Modifications

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...