高密度リポプロテインは,急性インフルエンザの感染中に抗炎症特性を失います
B J Van Lenten1, A C Wagner, D P Nayak
1Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA. bvanlent@mednet.ucla.edu
Circulation
|May 23, 2001
まとめ
インフルエンザ感染症は,高密度脂質タンパク質 (HDL) の組成を変化させ,その抗炎症能力を低下させます. この研究では,マウスの急性インフルエンザ期間中のHDLの変化を調査した.
科学分野:
- 心血管科学 心血管科学
- ウイルス学 ウイルス学 ウイルス学
- 免疫学 免疫学とは
背景:
- ウイルスは,動脈硬化症の発達に関与しています.
- インフルエンザAウイルスの感染は,心臓血管の健康に及ぼすウイルスの影響を研究するためのモデルとして機能します.
研究 の 目的:
- 高密度脂質タンパク質 (HDL) の機能性に対する急性インフルエンザ感染の影響を調査する.
- インフルエンザがHDLの抗アテロゲン特性にどのように影響するのかを判断する.
主な方法:
- C57BL/6Jマウスは,インフルエンザA株WSN/33.33で鼻内感染した.
- 感染後の様々な時点でのHDL成分 (パラオクソナーゼ,血小板活性化因子アセチルヒドロラーゼ,アポA-I,アポJ,セルロプラズミン) と機能性 (LDL酸化抑制,単細胞化学毒害) の分析.
- プラズマの炎症マーカー (インターリューキン-6,血清アミロイドA) の測定.
主要な成果:
- インフルエンザの感染は,HDLにおけるパラオクソナーゼと血小板活性化因子アセチルヒドロラーゼの活性低下につながった.
- HDLのLDLの酸化と単細胞化学作用を阻害する能力は,感染後減少した.
- 血中のインタールイキン6と血清アミロイドAの濃度が上昇し,炎症反応を示した.
結論:
- インフルエンザの急性感染はHDLの組成を変化させ,特にパラオクソナーゼ,血小板活性化因子アセチルヒドロラーゼ,セルーロプラズミン,ApoJのレベルに影響を及ぼします.
- これらのHDLの変異は,抗炎症特性を失うことにつながります.
- インフルエンザによって引き起こされるHDLの変化は,アテロゲネシスに寄与する可能性があります.
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