関連する実験動画

Updated: May 11, 2026

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
07:08

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration

Published on: August 1, 2013

インテグリンは,ヒポキャンパスのシナプスにおける機能的な前・後シナプス成熟を媒介する

P Chavis1, G Westbrook

  • 1CNRS UPR 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France. chavisp@ccipe.montp.inserm.fr

Nature
|May 18, 2001
PubMed
まとめ

インテグリンは,細胞結合分子の一種で,機能的な海馬シナプスの発達に不可欠です. インテグリンシグナル伝達を遮断すると,正常な成熟が妨げられ,中枢神経系のシナプス発達の役割が強調されます.

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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

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Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

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Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Integrins

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Activation of Integrins

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Intracellular Signaling Affects Focal Adhesions

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Integration of Synaptic Events

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