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LDL受容体関連タンパク質6は,Dickkopfタンパク質の受容体である

B Mao1, W Wu, Y Li

  • 1Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Nature
|May 18, 2001
PubMed
まとめ

Dickkopf1 (dkk1) は,Wntの信号共受容体であるLRP6と結合する. この相互作用は,Wnt/β-カテニンのシグナル伝達を阻害し,Dkkタンパク質が胚の発達中にWnt共受容体の機能に敵対する方法を明らかにします.

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