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Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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DNA Vector-based RNA Interference to Study Gene Function in Cancer
13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

癌の遺伝学 がん遺伝学

B A Ponder1

  • 1CRC Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK. bajp@mole.bio.cam.ac.uk

Nature
|May 18, 2001
PubMed
まとめ
この要約は機械生成です。

癌の研究は,がん細胞を超えて,表遺伝学と細胞の相互作用を含むように拡大しています. 遺伝的多様性と外部要因を理解することで,リスクの高い集団のがん予防戦略を向上させることができます.

さらに関連する動画

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

関連する実験動画

Last Updated: Jun 26, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

科学分野:

  • 腫瘍学 腫瘍学
  • 遺伝学 遺伝学とは
  • エピジェネティクス エピジェネティクス

背景:

  • 伝統的ながん遺伝学の研究は,がん細胞内の変異に焦点を当てていました.
  • 新興の証拠は,がんの発症における表遺伝子変化と細胞相互作用の重要性を強調しています.
  • 集団レベルでの癌の感受性における共通の遺伝的変異の役割は,認識を得ています.

研究 の 目的:

  • 癌研究の範囲を細胞内変異事件を超えて拡大する.
  • エピジェネティクス,細胞相互作用,一般的な遺伝的変異の影響をがん病因学に統合する.
  • ヒトゲノムプロジェクトのデータを活用して,人口の感受性を理解する.

主な方法:

  • エピジェネティックイベントと癌における細胞相互作用に関する現在の研究をレビューする.
  • 共通の遺伝的変異とそのがん感受性との関連に関するデータを分析する.
  • ヒューマンゲノムプロジェクトからの資源を利用する.

主要な成果:

  • 癌細胞の外から発症する癌の決定因子を特定した.
  • エピジェネティック改変と細胞間通信の重要性を強調した.
  • がんリスクに対する一般的な遺伝的変異の影響を認識した.

結論:

  • 将来のがん研究では,がん細胞以外の要因も考慮する必要があります.
  • 外的決定要因を研究することによって,治療的介入の新たな標的を特定することができます.
  • 遺伝的,環境的要因に基づいて,高リスクグループのために個別化された予防戦略を開発することができます.