ザ・ヘッジホッグとWntは,がんにおける信号伝達経路をシグナル化していない

J Taipale¹, P A Beachy

¹Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Nature

|May 18, 2001

まとめ

Wnt と Hedgehog (Hh) のシグナル伝達経路は,胚の発達と成人幹細胞数を調節する. これらの経路の異常な活性化は,潜在的に幹細胞のような運命を誘導することによって,癌に関連しています.

科学分野:

発達生物学発達生物学について
細胞シグナル伝達細胞信号伝達
腫瘍学腫瘍学

背景:

WntとHh経路は,胚の発達と組織再生に不可欠です.
これらの経路は,皮膚や腸のような成人の上皮質の幹細胞集団を調節する.
構成経路の活性化につながる変異は,ヒトの癌で頻繁に観察されます.

研究の目的:

HhとWntの信号伝導が発達と癌における役割を検討する.
経路の活性化と腫瘍発生の関連性を探求する.
経路の活性化が幹細胞の誤った特異化につながる可能性があるという仮説について議論する.

主な方法:

WntとHh信号に関する研究の文献レビュー.
経路変異を癌と結びつける証拠の分析.
経路主導の腫瘍発生のための提案されたメカニズムの検討.

主要な成果:

WntとHh経路は,正常な成長とパターン形成に不可欠です.
これらの経路は,成人の組織における幹細胞の恒常性を維持する役割を果たします.
WntとHhシグナル伝達の構成的活性化は,様々ながんの共通特徴である.

結論:

WntとHhのシグナル伝達の不調は,がんの発症に寄与する.
これらの経路に関連する腫瘍発生は,幹細胞のような特性の誘導から生じる可能性があります.
これらの経路を理解することは,がん治療の潜在的な治療目標を提供します.

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