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Updated: Jun 21, 2026

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
血管の硬化が減ったとすると,高齢で身体的に活動的な男性における心血管内気反射機能の保全が完全に説明できるのでしょうか
B E Hunt1, W B Farquhar, J A Taylor
1Laboratory for Cardiovascular Research, Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, MA 02131, USA. hunt@mail.hrca.harvard.edu
Circulation
|May 23, 2001
まとめ
カーディオ・ヴァーガル・バロレフレクスの増加の年齢関連の低下は,血管および神経の欠陥と関連しています. 身体活動は,神経管の制御を維持し,高齢者のこれらの低下を弱めるのに役立ちます.
科学分野:
- 心血管の生理学 心血管の生理学
- 自律神経系の機能は,自律神経系の機能である.
- 老化に関する研究.
背景:
- 心血管バロレフレクスの増加は,血圧の恒常性を維持するために重要です.
- バロレフレクスの機能の年齢関連の低下は,心血管疾患のリスクの増加と関連しています.
- バロレフレクスの増強の構成要素を理解することは,ターゲットを絞った介入に不可欠です.
研究 の 目的:
- 心血管内気反射の増強とその血管の機械的および神経的構成要素を測定する.
- これらの構成要素に対する老化と身体活動の影響を調査する.
- バロレフレクスの獲得に対する機械的および神経伝導の貢献を区別する.
主な方法:
- バロレフレクスの関与中にビート・トゥ・ビート (ビート・トゥ・ビート) の頸動脈直径を評価するための新しい方法を開発した.
- 測定された機械伝導 (直径/圧力),神経伝導 (R-R区間/直径),および統合された心血管バロレフレクスの増加 (R-R区間/圧力).
- 訓練を受けていない若い男性,訓練を受けていない高齢の男性,そして身体的に活発な高齢の男性で,これらの測定値を比較した.
主要な成果:
- 統合心血管バロレフレクスの獲得は,訓練を受けていない若い男性と比較して,訓練を受けていない高齢の男性では著しく低かった.
- この減少は,機械的伝導と神経伝導の両方の欠陥に起因する.
- 身体的に活発な年配の男性は,若い男性と比べて,心血管内気反射の増加を示し,訓練を受けていない年配の男性と比較して,機械的および神経伝導の改善を示した.
- 神経伝導は,機械的伝導よりも統合的増益のためのより大きな予測重量を示した.
結論:
- 心血管内気反射力の年齢関連の低下は,血管の機械的および神経的欠陥の両方によるものです.
- 長期の身体活動により,加齢に伴う心血管内気反射の低下を弱めることができます.
- 身体活動は,主に神経管の制御を保ち,バロレフレクスの機能の重要な構成要素である.
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