ネズミで誘発された衝動的な選択は,核アキュメンズ核の損傷によって引き起こされた
R N Cardinal1, D R Pennicott, C L Sugathapala
1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. rudolf.cardinal@pobox.com
Science (New York, N.Y.)
|May 26, 2001
まとめ
ネズミの選択性核アキュンベンスの核病変は,衝動的な選択を継続的に誘導した. これは,核アクンベンスの核機能不全が衝動性の鍵であり,中毒や精神疾患に影響を及ぼすことを示唆しています.
科学分野:
- 神経科学は神経科学である.
- 行動科学は,行動科学である.
背景:
- 衝動的な選択は,より大きな遅延されたものよりも,即時の小さな報酬を好むことで,中毒と精神疾患に関連しています.
- 衝動的な選択の基礎となる神経解剖学的基礎は,依然として大きく未決定のままである.
- 衝動性の神経回路を理解することは,効果的な治療法の開発に不可欠です.
研究 の 目的:
- 衝動的な選択の神経解剖学的基礎を調査する.
- 衝動的選択行動の調節における核アクンベンズ核の役割を決定する.
- 前帯状皮質と中部前頭前皮質が衝動的な選択に及ぼす影響を調べる.
主な方法:
- ネズミのアキュメンズ核に選択的な病変を誘発する.
- これらの病変が意思決定行動,特に衝動的な選択に与える影響を評価する.
- 前帯状皮質と中央前頭前皮質の病変が衝動的選択に及ぼす影響を評価する.
主要な成果:
- 核アキュンベンスの選択的病変は,ネズミの持続的な衝動的な選択につながった.
- 前帯状皮質の損傷は,衝動的選択行動に影響を与えなかった.
- 中部前頭前皮質の損傷は,衝動的な選択を変化させなかった.
結論:
- 核は,衝動的選択の基礎となる神経回路において重要な役割を果たします.
- nucleus accumbens coreの機能障害は,衝動性の神経病理学における重要な要因である可能性があります.
- これらの発見は,衝動性によって特徴づけられる障害を理解し,潜在的に治療するための神経解剖学的標的を提供します.
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