長距離飛行における無症状深静脈血栓の頻度と予防:ランダム化試験
J H Scurr1, S J Machin, S Bailey-King
1Department of Surgery, Royal Free and University College Medical School, London, UK. medleg@mailbox.co.uk
Lancet (London, England)
|May 30, 2001
まとめ
深い静脈栓塞 (DVT) は,長距離旅行者の最大10%に影響を与える可能性があります. 漸縮弾性圧縮ストッキングの着用は,航空旅行中にDVTを発症するリスクを大幅に軽減します.
科学分野:
- 血管医学 血管医学とは
- 旅行 医療 医療
- トロンボシス研究研究
背景:
- 深静脈動脈栓塞 (DVT) は,長時間不動状態中の既知のリスクです.
- 長距離航空旅行におけるDVTの正確な発生率は未確定のままである.
- この研究は,エコノミークラスの航空旅客におけるDVTの頻度と予防を調査しています.
研究 の 目的:
- 長距離フライトの乗客における下肢DVTの発生率を決定する.
- DVTを予防する段階的な弾性圧縮ストッキングの有効性を評価する.
- 航空旅客におけるDVTの潜在的な危険因子を特定する.
主な方法:
- 前回の血栓塞栓症のない50歳以上の231人の乗客 (89人の男性,142人の女性) のコホートを募集しました.
- 参加者は,クラスIの膝下段落弾性圧縮ストッキングを着用するか,着用しないようにランダムに割り当てられました.
- デュプレックス超音波検査,D-ダイマー測定,およびファクターV・ライデンとプロトロンビンG20210A変異の遺伝子分析が行われました.
主要な成果:
- 圧縮ストッキングを着用していない乗客の10% (12/116) で無症状の小牛のDVTが発生しました.
- 漸縮弾性圧縮ストッキング (95%CI 0-3.2%) を着用したグループでは,DVTの症例は観察されなかった.
- ストッキングを着用した4人の乗客は,表面性血栓炎を発症し,そのうちの1人はファクターV・ライデンとプロトロンビンG20210Aの変異を有する.
結論:
- 症状のないDVTは大きなリスクであり,長距離航空旅行者の最大10%に影響を与える可能性があります.
- 漸縮弾性圧縮ストッキングは,航空旅行中にDVTの発生率を減らすのに有効性を示しています.
- 将来の研究は,航空旅行に関連するDVTにおける遺伝的傾向およびその他のリスク要因を調査する可能性がある.
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