コカインの単発暴露は,ドーパミンニューロンの長期的な増強を誘発する

M A Ungless1, J L Whistler, R C Malenka

  • 1Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA.

Nature
|June 1, 2001
PubMed
まとめ

コカインの単発暴露は,脳細胞の接続に持続的な変化を引き起こし,特にアルファ-アミノ-3-ヒドロキシ-5-メチル-イソクサゾールプロピオニック酸受容体の活性を強化します. これらの神経の変化は,薬物依存症の発生に役割を果たす可能性があります.

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