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Updated: Jun 24, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

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Published on: April 4, 2018

NOD2のフレームシフト変異は,クローン病の感受性に関連しています

Y Ogura1, D K Bonen, N Inohara

  • 1Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Nature
|June 1, 2001
PubMed
まとめ

NOD2遺伝子の特定の変異は,慢性的な胃腸疾患であるクローン病 (CD) と関連しています. このNOD2遺伝子変異は,細菌の成分に対する免疫反応を低下させ,CD発達の新たな経路を示唆する.

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