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Updated: Jun 24, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
13:40

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms

Published on: July 7, 2011

細胞表面でのCa2+チャネル発現を小さなGタンパク質kir/Gemによって調節する

P Béguin1, K Nagashima, T Gonoi

  • 1Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Nature
|June 8, 2001
PubMed
まとめ

小型Gタンパク質kir/Gemは,βサブユニットと結合することで,高電圧活性化カルシウム (Ca2+) チャンネルを抑制する. この相互作用は,細胞表面のCa2+チャネル発現を減少させ,ホルモン分泌細胞のCa2+誘発エクソサイトーシスに影響を与えます.

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