急性心筋梗塞の患者における内皮原始細胞の動員

S Shintani¹, T Murohara, H Ikeda

¹Cardiovascular Research Institute and Department of Internal Medicine III, Kurume University, Japan.

Circulation

|June 13, 2001

まとめ

内皮原生細胞 (EPCs) とその前駆体は,ヒトにおける急性不全性イベント中に外周血液に動員される. この研究では,心筋梗塞後のEPCとCD34陽性単核細胞の増加が示されています.

科学分野:

心血管科学の研究について
幹細胞生物学幹細胞生物学
再生医学は,再生医療である.

背景:

内皮原生細胞 (EPC) は,外周血液に存在し,新血管化を助けます.
ヒトにおける急性性不血症イベントにおけるEPCとその前駆体 (CD34陽性単核細胞,MNC ((CD34+)) の動員は十分に理解されていません.

研究の目的:

急性不血症イベントを経験する患者のEPCとMNCの動員を調査する.
これらの細胞と血管内皮成長因子 (VEGF) レベルとの関係を決定する.

主な方法:

フローサイトメトリーは,急性心筋梗塞 (AMI) の患者および対照群の循環中のMNC (CD34+) 数を定量化するために使用されました.
外周血液単核細胞 (PB-MNCs) は,EPC形成を評価するために培養されました.
血のVEGF濃度が測定され,MNC ((CD34+)) 数値と相関しました.

主要な成果:

循環中のMNC ((CD34+) 数値は,AMI患者で著しく増加し,対照群とは異なり,発症後7日目にピークに達しました.
AMI患者の培養PB-MNCは,1日目と比較して7日目により多くのEPCクラスターとEPCを生成しました.
血のVEGF濃度は7日目にピークに達し,MNC ((CD34+) 数と正に相関しています.

結論:

この研究は,ヒトにおける急性不血症イベント中にEPCおよびMNC (CD34+) の動員に関する最初の臨床的証拠を提供します.
モビライズされたEPCとその前駆体は,急性イシュケミアの反応に役割を果たす可能性があります.

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