選択したフラボノイドと紫のブドウの果汁は,血小板機能を抑制し,酸化窒素の放出を促進します
1Departments of Pharmacology and Medicine, Georgetown University Medical Center, Washington, DC 20007, USA. freedmaj@gunet.georgetown.edu
Circulation
|June 13, 2001
まとめ
紫のブドウジュース (PGJ) の摂取は,血小板の蓄積を抑制し,酸化窒素 (NO) の放出を促進し,潜在的に心血管疾患のリスクを軽減します. これらの効果は,PGJのフラボノイドに起因し,アルコールとは独立した利点を提供します.
科学分野:
- 心血管科学 心血管科学
- 栄養科学とは,栄養科学である.
- バイオケミストリー バイオケミストリー
背景:
- 適度な赤ワインの消費は,冠動脈不全の減少と関連しています.
- 赤ワインと紫のブドウジュース (PGJ) に含まれるフラボノイドは,抗酸化および抗血小板性を持っています.
- 急性心臓発作は,血小板由来窒素酸化物 (NO) の放出が減少したものと相関しています.
研究 の 目的:
- 血小板機能に対するPGJとそのフラボノイドの影響を調査する.
- 血小板酸化窒素 (NO) 産生に対するPGJの影響を決定する.
主な方法:
- 稀なPGJで血小板のインビトロインキュベーション.
- 20人の健康な被験者にPGJ (7mL/kg/日14日間) を経口補充した.
- 血小板の集積,NOの放出,超酸化物産生,アルファトコフェロール濃度の分析.
主要な成果:
- PGJは血小板の集積を阻害し,インビトロとインビボの両方でスーパーオキシドの産生を減少させた.
- PGJサプリメントは,血小板由来のNOの生成を有意に増加させました (3.5〜6.0 pmol/10(8) 血小板).
- アルファトコフェロール濃度とプラズマの抗酸化作用は,PGJの摂取後に著しく増加した.
結論:
- PGJの摂取は,血小板の集積と超酸化物の生成を減少させ,血小板由来NOを増加させる.
- 抗酸化物質を節約する効果と直接的なフラボノイド作用は,これらの心臓血管の利点に寄与する可能性があります.
- PGJによる血小板凝集の減少と血栓形成抑制は,アルコールとは関係なく,心臓血管の保護のための潜在的なメカニズムを提供します.
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