GGとCGのステップに中性電荷インターケレーターの選択的インターケレーション:DNAへの配列選択薬物インターケレーションに対するHOMO-LUMO相互作用の意味

K Nakatani1, T Matsuno, K Adachi

  • 1Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, CREST, Japan Science and Technology Corporation (JST), Kyoto 606-8501, Japan.

まとめ

ナフトピラノンエポキシド4はDNA内のグアニン (G) 残基を選択的にアルキル化し,DNA配列に依存する活性を持つ. このDNAアルキル化活動は,グアニンを含む配列の最も高い占有分子軌道 (HOMO) エネルギーレベルと相関しています.

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