ヘリコバクター・ピロリ菌と胃食道逆流症の症状的な再発:ランダム化制御試験
W Schwizer1, M Thumshirn, J Dent
1Department of Gastroenterology, University Hospital, CH-8091, Zurich, Switzerland. gasschwi@usz.unizh.ch
Lancet (London, England)
|June 14, 2001
まとめ
胃食道逆流性疾患 (GORD) の患者におけるヘリコバクター・ピロリ (H pylori) 感染症の根絶は,症状が再発するまでの時間を延長することがあります. H pyloriの根絶は,GORDの再発率を減らすのに役立ちます.
科学分野:
- 胃腸内科 胃腸内科
- 微生物学 微生物学とは
背景:
- 胃食道逆流性疾患 (GORD) の患者におけるヘリコバクター・パイロリ (H pylori) 根絶効果に関するデータは限られている.
- GORD再発に対するH・パイロリ根絶の影響を調査することは極めて重要です.
研究 の 目的:
- GORDの再発率に対するH・ピロリ根絶の効果を判断する.
- H. pyloriの根絶が,GORD患者における無病間隔を延長できるかどうかを評価する.
主な方法:
- 70人のGORD患者を含むダブルブラインド,ランダム化,プラセボ対照試験です.
- ランソプラゾルを投与した患者と,H・ピロリ感染した患者は,10日間,抗生物質またはプラセボを投与された.
- フォローアップには,症状モニタリング,内視鏡検査,24時間PHモニタリングが6ヶ月間行われました.
主要な成果:
- H pylori陽性患者は,根絶されたH pylori (100日) またはH pylori陰性対照群 (110日) よりも有意に早く (54日) 再発しました.
- 胃腸炎のグレードはまた,重発時間に影響を与え,重度の胃腸炎は早期の再発につながった.
- 消化管炎を調整した後も,H・パイロリ陽性患者は,根絶されたグループや対照グループと比較して,早期に再発を示した.
結論:
- H pylori 感染症は,より高い GORD 再発率と関連しています.
- H pyloriの根絶は,GORD患者の病気のない期間を潜在的に延長することができます.
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