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Updated: Jul 16, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

アルファ・ヘリックスと3・10・ヘリックス相互変換: ガス相および水溶剤中のポリアラニン系に関する量子化学的研究

I A Topol1, S K Burt, E Deretey

  • 1Advanced Biomedical Computing Center, SAIC Frederick, P.O. Box B, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA. topol@ncifcrf.gov

Journal of the American Chemical Society
|June 21, 2001
PubMed
まとめ

タンパク質ヘリクスは,主として真空では3(10) 形状を採用するが,水ではアルファヘリク構造に切り替わる. これらの発見は,タンパク質の折り畳みダイナミクスと二次構造の好みに光を当てています.

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
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