血小板の集積に対する遺伝的および環境的貢献:フレミングハム心臓研究
C J O'Donnell1, M G Larson, D Feng
1National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. chris@fram.nhlbi.nih.gov
Circulation
|June 27, 2001
まとめ
遺伝的要因は,動脈血栓形成の重要なプロセスである血小板の集積を著しく影響する. この研究で発見された遺伝性は,環境要因よりも,血小板の反応における変動のかなりの部分を説明する.
科学分野:
- 心血管遺伝学 心血管遺伝学
- 血液学 ヘマトロジ
- トロンボシス研究研究
背景:
- 血小板の集積は,心血管疾患に関与する動脈血栓症において極めて重要です.
- 血小板集積の変動性における遺伝的および環境的要因の相互作用は十分に理解されていません.
研究 の 目的:
- 血小板集積反応の遺伝性を調査するために.
- 血小板の集積能力に対する遺伝子と環境の影響の貢献を定量化するために.
主な方法:
- フレミングハム心臓研究 (Framingham Heart Study) に参加した2413人の血小板の集積の分析.
- 混合モデル線形回帰とバリエンス/共バリエンスコンポーネントのメソッドを使用した.
- エピネフリン,ADP,およびコラーゲンへの評価応答の遅延時間.
主要な成果:
- 血小板集積の測定値において,兄弟同士の有意な相関関係 (0.24-0.31) が認められ,配偶者同士の有意でない相関関係とは対照的である.
- 血小板集積の推定遺伝性は0.44から0.62.6の範囲であった.
- 遺伝的要因は,変数の20~30%を占め,測定された共変数は4~7%しか説明できませんでした.
結論:
- 遺伝的要因は,集団ベースのサンプルにおける血小板集積の主要な決定因子である.
- 環境的共変数は,血小板集積の変動性においてそれほど重要な役割を果たさない.
- 薬剤遺伝学的な応用のために,血小板機能を調節する特定の遺伝的変異を特定するために,さらなる研究が必要です.
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