超音波の光性動脈プラークは,将来の脳卒中を予測する
M L Grønholdt1, B G Nordestgaard, T V Schroeder
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan. mlg@dadlnet.dk
Circulation
|July 4, 2001
まとめ
エコロセント性頸動脈プラークは,症状のある患者の脳卒中リスクを予測しますが,無症状の患者はそうではありません. プラークの回度および狭窄度が,脳卒中リスクの評価と頸動脈末関節切除手術の患者の選択を改善する可能性があります.
科学分野:
- 神経学 神経学とは
- 血管医学 血管医学とは
- メディカルイマージング (医学イメージング)
背景:
- 動脈の狭窄は,不全性脳卒中の重要な危険因子です.
- 動脈動脈動脈硬化症患者の脳卒中のリスクを予測することは,依然として臨床的な課題です.
- エコロセンシーなどのプラークの特徴は,予後的な価値を提供することができます.
研究 の 目的:
- 頸動脈斑のエコロシエンシーが脳卒中発症を予測するかどうかを前向きに評価する.
- この予測を,以前に症状のある患者と無症状の患者の両方において評価する.
- 音響が脳卒中リスクの階層化を狭窄度を超えて改善するかどうかを判断する.
主な方法:
- 246人の患者 (111人無症状,135人有症状) を対象とした前向きな研究で,大動脈狭窄症 >=50%でした.
- コンピュータ支援画像処理による高解像度Bモード超音波により,プラックのエコージェニシティが評価されました.
- ドップラー超音波は,大動脈狭窄の程度を評価した.
- ipsilateral ischemic strokeのフォローアップは,4.4年にわたって行われました.
主要な成果:
- フォローアップ中に44のipsilateral ischemic ストロークが観察されました.
- 症状のある患者では,エコロセントプラークが脳卒中リスクを大幅に増加させた (相対リスク=3.1).
- 症状のある患者では,より高い狭窄症 (80-99%) がリスク増加 (RR=1.4) の傾向を示したが,声明瞭性はより強い予測因子であった.
- 無症状の患者では,プラークエコロセンシーと脳卒中リスクとの間に有意な関連性が見つかりませんでした.
結論:
- エコロセント性頸動脈プラークは,重大な狭窄症の症状のある個体において,将来の脳卒中リスクと関連しています.
- 狭窄症の重症度に加えて,プラークエホルセンシーは,大動脈末関節切除術の患者の選択を強化する可能性があります.
- このイメージングマーカーは,大動脈狭窄症の無症状患者の脳卒中リスクを予測することができないようです.
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