ベータ(1) - アドレナゲン受容体遺伝子と高血圧の多形態化
K Bengtsson1, O Melander, M Orho-Melander
1Department of Endocrinology, Malmö University Hospital, Lund University, Sweden. kristina.a.bengtsson@vgregion.se
Circulation
|July 12, 2001
まとめ
ベータ(1) - アドレナゲン受容体遺伝子のArg389アレルの2つのコピーを持つ個人は,高血圧を発症するリスクが高くなります. この遺伝子変異は,血圧上昇と心拍数上昇と関連しています.
科学分野:
- ファルマコゲノミクスは,
- 心血管遺伝学 心血管遺伝学
背景:
- ベータ(1) - アドレナゲン受容体遺伝子は,受容体活性に影響を与える変種 (Arg389とGly389) を有しています.
- これまでのインビトロ研究では,Arg389はアデニラートサイクラースの活性性を高めることを示しています.
研究 の 目的:
- ベータ(1) - アドレナゲン受容体遺伝子ポリモルフィズム (Arg389Gly と Ser49Gly) とスカンジナビア人群における高血圧との関連を調査する.
主な方法:
- 症例対照研究では,高血圧患者292人,健康な対照患者265人が参加しました.
- 兄弟のペア研究では,Arg389Glyのポリモルフィズムに不一致する102の非糖尿病の兄弟のペアを分析した.
- ゲノタイプとアレル周波数を比較し,血圧と心拍数を分析した.
主要な成果:
- Arg389アレルの同同胞性は,高血圧の確率比1.9倍増加 (P=0.0005) と関連していました.
- Arg389の同位体の兄弟姉妹は,Gly389のキャリアと比較して,ダイアストリック血圧 (P=0.003) と心拍数 (P=0.02) が著しく高かった.
- Ser49Glyのポリモルフィズムが高血圧と関連していない.
結論:
- ベータ(1) - アドレナゲン受容体遺伝子のArg389アレルは,高血圧を発症させる危険因子である.
- Arg389に同位体性を持つ個人は高血圧のリスクが高くなります.
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