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Updated: Jul 8, 2026

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
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アレルギー反応におけるGab2の重要な役割

H Gu1, K Saito, L D Klaman

  • 1Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA hgu@caregroup.harvard.edu.

Nature
|July 13, 2001
PubMed
まとめ

Gab2は,IgE受容体の活性化に対するマスト細胞の反応に不可欠です. Gab2が欠けているマウスは,アレルギー反応の障害を示し,Gab2が免疫におけるPI(3) Kシグナル伝達の主な活性化剤であることを強調しています.

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