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関連する概念動画

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...

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関連する実験動画

Updated: Jun 29, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

グローメルーラ上皮質:ポリケーションによって引き起こされる構造的変化.

M W Seiler, M A Venkatachalam, R S Cotran

    Science (New York, N.Y.)
    |August 1, 1975
    PubMed
    まとめ
    この要約は機械生成です。

    プロタミン硫酸塩の輸液はネズミの腎臓損傷を誘発し,腎臓症候群を模倣した. その後のヘパリン注入は,これらの有害な球上皮質の変化を大きく逆転させました.

    さらに関連する動画

    Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
    10:34

    Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

    Published on: April 23, 2017

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
    07:30

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

    Published on: June 28, 2024

    関連する実験動画

    Last Updated: Jun 29, 2026

    Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
    09:14

    Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

    Published on: August 22, 2016

    Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
    10:34

    Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

    Published on: April 23, 2017

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
    07:30

    Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

    Published on: June 28, 2024

    科学分野:

    • ネフロロジーはネフロロジーを用います.
    • 腎臓生理学 腎臓生理学
    • 病理学 パトロジー

    背景:

    • 腎不全状態は,重大な腎臓損傷によって特徴付けられます.
    • グロメルーラ上皮細胞は,腎臓の機能と整合性において重要な役割を果たします.
    • ポドサイト損傷のメカニズムを理解することは,治療法の開発に不可欠です.

    研究 の 目的:

    • ネズミの腎臓のグルメルリにプロタミン硫酸が及ぼす影響を調査するために.
    • その結果生じる球上皮質の変異を特徴づけるために.
    • ヘパリンを用いてこれらの変化を逆転させる可能性を評価する.

    主な方法:

    • ネズミの腎臓に,ポリケーションであるプロタミン硫酸塩を注入した.
    • グローメラルの上皮の変化を調べました.
    • 逆転を評価するために,ポリアニオンであるヘパリンによる後の輸液が行われました.

    主要な成果:

    • プロタミン硫酸精液 perfusionは,足の球上皮質プロセスに腫れ,鈍化し,平らになった.
    • これらの変異は,ヒトと実験的な腎臓病状態で見られる変化を模倣した.
    • その後のヘパリン注入は,観察された球上皮損傷を大きく逆転させました.

    結論:

    • プロタミン硫酸酸などのポリケーションは,重大な球上皮損傷を引き起こす可能性があります.
    • 観察された損傷は,腎臓病状態の重要な特徴に似ている.
    • ヘパリンなどのポリアニオンは,そのような損傷を逆転させるための治療的な役割を果たす可能性があります.