軽度の全身性低体温症による新生児ハイパーアモネミア性昏睡の緊急治療
Lancet (London, England)
|July 17, 2001
まとめ
治療性低体温症は,尿素循環欠陥のある新生児のハイパーアモネミア性昏睡を成功裏に治療しました. 冷却によりアンモニアの生成が低下し,非酵素による毒素の除去が可能になり,回復に至った.
科学分野:
- バイオケミストリー バイオケミストリー
- 新生児医学 新生児医学
- メタボリック障害 メタボリック障害
背景:
- 尿素循環欠陥は,アンモニアの解毒を阻害する遺伝疾患である.
- 新生児のハイパーアモネミック・コマは,生命を脅かす医療的緊急事態である.
- ヘモフィルトレーションや代謝介入などの標準的な治療は効果がなかった.
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