フェノフィブラートとゲムフィブロジルのプラズマホモシステインに対する作用
Lancet (London, England)
|July 17, 2001
まとめ
フェノフィブラートはゲンフィブロジルとは異なり,腎臓機能を低下させることでホモシステインを増加させます. この研究では,ガムフィブロジルは,繊維酸治療を必要とする高トリグリセリデミアの患者にとってより安全な選択であることを示唆しています.
科学分野:
- 薬理学 薬理学とは
- ネフロロジーはネフロロジーを用います.
- クリニカル・メディシン 臨床医学
背景:
- フェノフィブラートは,血のホモシステインレベルを上昇させることが知られている.
- 血ホモシステイン濃度は,腎機能によって影響を受けます.
- 繊維酸は,高トリグリセリデミアの治療に使用される薬のクラスです.
研究 の 目的:
- ゲンフィブロジル (別の繊維酸) が血ホモシステインを増加させるかどうかを調査する.
- フェノフィブラートとゲムフィブロジルのホモシステインと腎機能マーカーに対する効果を比較する.
主な方法:
- ハイパルトリグリセリデミアの22人の患者を対象としたクロスオーバー研究.
- 患者は6週間にわたって毎日900mgのゲンフィブロジルまたは200mgのフェノフィブラートを受けた.
- 測定には,プラズマのホモシステイン,クレアチニン,シスタチンCレベルが含まれていました.
主要な成果:
- フェノフィブラートとゲムフィブロジルの両方とも,同様に脂質プロフィールを変化させた.
- フェノフィブラートはホモシステイン,クレアチニン,シスタチンCを有意に増加させた.
- ジェムフィブロジルは,これらのパラメータの有意な増加を示さなかった.
結論:
- ホモシステインに対するフェノフィブラートの効果は,腎機能障害による可能性が高い.
- ジェムフィブロジルは腎機能やホモシステインレベルに影響を与えないようです.
- ジェムフィブロジルは,高トリグリセリデミア治療の好ましい繊維素として推奨されています.
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